HCID 118006851, compound → tert-Butyl (3S,4S)-3-amino-4-fluoropyrrolidine-1-carboxylate

Participants

Reaction Steps

(3S,4S)-tert-butyl 3-(benzylamino)-4-fluoropyrrolidine-1-carboxylate, 82 (24 mg, 0.082 mmol) was subjected to hydrogenolysis with 10 wt % Pd—C(10 mg) in ethanol (3 ml). The reaction mixture was filtered, concentrated and azeotroped dry with CHCl3 to provide (3S,4S)-tert-butyl 3-amino-4-fluoropyrrolidine-1-carboxylate (16.6 mg, 0.081 mmol, 99.2% yield) that was used in the next step without purification.

Provenance & Evidence