HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → HCID 1078643, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | (+)-Benzyl glycidyl ether | HCID 146296 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 1078643 | HCID 1078643 | 98% |
Reaction Steps
ER-886133 and ER-886134: A solution of (S)-2-((benzyloxy)methyl)oxirane (65 g, 0.396 mol) and 28% NH4OH in water was stirred at rt for 14 h after which time the completed reaction was concentrated and azeotroped two times with toluene (150 mL each) to obtained (S)-1-amino-3-(benzyloxy)propan-2-ol (70.6 g, 0.390 mol, 98% yield) as a crude white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09428495B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-7ec09a6c130048759f4303e14635cffe |
| Source note | uspto-grants-2016_08 |