Trityl chloride → HCID 71246274, compound

Participants

Reaction Steps

217 mg (0.94 mmol, 1 eq) of (−)-[5-(8-aza-bicyclo[3.2.1]oct-6-yl)-pyridine-2-yl]-dimethylamine (VII-1) are dissolved in 1 ml of chloroform. 195 μL (1.4 mmol, 1.5 eq) of TEA and 274 mg (0.98 mmol, 1.05 eq) of tritylchloride are added. After stirring for 1 and 2.5 h at RT 195 μL (1.4 mmol, 1.5 eq) of TEA and 274 mg (0.98 mmol, 1.05 eq) of tritylchloride are added. After stirring for a total of 4 h at RT it is diluted with EE. It is washed once with water, the aqueous phase is re-extracted twice with EE. The combined organic phases are dried over sodium sulphate and the solvent is removed in vacuo. The crude product is purified by column chromatography (EE:hex=1:3). 158 mg (0.33 mmol, 35%) of a colorless foam is obtained.

Provenance & Evidence