Methanesulfonyl chloride → HCID 84332484, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 6-aminopyridine-3-carboxylate (738 mg, 4.44 mmol) was dissolved in pyridine (20 mL), cooled to 0° C. and methanesulfonyl chloride (1.72 mL, 22.2 mmol) was added. The reaction mixture was stirred at room temperature for 16 h, concentrated in vacuo and partitioned between DCM (50 mL) and 1M aq citric acid (50 mL). The organic fraction was dried (MgSO4) and concentrated in vacuo to give the crude title compound (1.34 g) as a brown solid. LCMS (ES+): 245.1 [MH]+.

Provenance & Evidence