HCID 89893838, compound → HCID 72195746, compound

Participants

Reaction Steps

9-Benzenesulfonyl-6-[4-(4-methylpiperazin-1-yl)-phenyl]-4-phenylethynyl-9H-pyrido[2,3-b]indole underwent typical procedure A. The trituration procedure in MeOH afforded the desired compound in 81% yield as a brown solid. 1H-NMR (300 MHz, DMSO) δ=12.07 (s, 1H), 8.69 (d, J=2.2 Hz, 1H), 8.46 (d, J=5.1 Hz, 1H), 7.82-7.74 (m, 3H), 7.63-7.54 (m, 6H), 7.34 (d, J=5.1 Hz, 1H), 7.04 (d, J=8.7 Hz, 2H), 3.23-3.14 (m, 4H), 2.49-2.44 (m, 4H), 2.24 (s, 3H). 13C-NMR (101 MHz, DMSO) δ=152.27 (Cq), 149.85 (Cq), 145.83 (CH), 137.99 (Cq), 132.28 (Cq), 131.46 (2 CH), 131.23 (Cq), 129.68 (CH), 128.97 (2 CH), 126.94 (2 CH), 125.66 (CH), 122.62 (Cq), 121.43 (Cq), 120.52 (Cq), 118.69 (CH), 116.77 (CH), 115.58 (2 CH), 114.46 (Cq), 111.68 (CH), 96.75 (Cq), 86.54 (Cq), 54.42 (2 CH2), 47.87 (2 CH2), 45.54 (CH3). HRMS (ESI): calcd. for C30H27N4: 443.2230. found: 443.2247.

Provenance & Evidence