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HRID1486853

反应详情

EQUATION

反应方程式

HRID 1486853 的结构方程式

REACTANTS

反应物

1
反应SMILES：CC(C)(C)OC(=O)CC1(C(=O)OC(C)(C)C)CC(c2cccc(O)c2)=NO1
HCID118292884

未命名化合物

PRODUCTS

产物

1
反应SMILES：CC(C)(C)OC(=O)C[C@]1(C(=O)OC(C)(C)C)CC(c2cccc(O)c2)=NO1
HCID131736824

未命名化合物

收率 49.1%

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：CCCCCC.CCO
溶剂HCID21879635

未命名化合物

PROCEDURE

实验过程

A racemate of tert-butyl 5-(2-tert-butoxy-2-oxoethyl)-3-(3-hydroxyphenyl)-4,5-dihydro-1,2-oxazole-5-carboxylate (49.5 g) was fractionated by HPLC (column: CHIRALPAK AD (trade name), 50 mm ID×500 mm L, mobile phase: hexane/ethanol=850/150) to obtain the title compound (24.3 g) eluted at a larger retention time.