Hydrochloric Acid → HCID 118292770, compound

Participants

Reaction Steps

A mixture of 3-(2-(5,5-bis(2-tert-butoxy-2-oxoethyl)-4,5-dihydro-1,2-oxazol-3-yl)-4-hydroxyphenyl)propanoic acid (317 mg), thiomorpholine 1,1-dioxide (92 mg), WSC (106 mg), HOBt (92 mg), and DMF (3 mL) was stirred at room temperature for 7 hours. To the reaction mixture, 0.1 M hydrochloric acid was added, followed by extraction with ethyl acetate. The extract was washed with brine and dried over anhydrous magnesium sulfate, and then, the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to obtain the title compound (140 mg).

Provenance & Evidence