Trifluoroacetic acid → HCID 178512540, compound

Participants

Reaction Steps

A mixture of 3-(5,5-bis(2-tert-butoxy-2-oxoethyl)-4,5-dihydro-1,2-oxazol-3-yl)-4-(3-(1,1-dioxidothiomorpholin-4-yl)-3-oxopropyl)phenyl 4-carbamimidamidobenzoate (49.0 mg) and TFA (1 mL) was stirred at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure, and then, the pH of the residue was adjusted to about 4 by the addition of water and subsequently a saturated aqueous solution of ammonium acetate. The obtained mixture was stirred at room temperature for 3 days, and then, the obtained solid was collected by filtration and washed with water and acetone to obtain the title compound (33.1 mg).

Provenance & Evidence