Lithium borohydride → HCID 86731583, compound

Participants

Reaction Steps

Methyl 3-(N-(2,4-dimethylphenyl)-N-isobutylsulfamoyl)benzoate (400 mg, 1.065 mmol) was dissolved in tetrahydrofuran (THF) (10 mL). To this solution was added lithium borohydride (2 M in THF) (0.932 mL, 1.864 mmol). The reaction was left to stir overnight, at room temperature. The reaction was quenched by the addition of 5% citric acid (10 mL), and the reaction allowed to stir under nitrogen, for 1 hour. The reaction mixture was then diluted with ethyl acetate (25 mL), and the product extracted to the organic phase. The organic phase was dried by passing it through a hydrophobic frit and then concentrated in vacuo to give the desired product, 378.7 mg. LCMS [LCMS1] Rt 1.23 min, m/z (ES+) 348 (M+H).

Provenance & Evidence