Ethanol → HCID 72191132, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-(2,4-dimethylphenyl)-2-hydroxy-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide (15.7 mg, 0.035 mmol) and ethanol (4.8 mg, 0.105 mmol) in toluene (1.5 mL) stirred in air at 20° C., was added a solution of 2-(tributylphosphoranylidene)acetonitrile (8.47 mg, 0.035 mmol) in toluene (0.5 mL) over 1 minute. The reaction mixture was stirred at 20° C. for 24 hours. Additional 2-(tributylphosphoranylidene)acetonitrile (8.47 mg, 0.035 mmol) was then added and the reaction stirred for a further 2 hours. The solvent was evaporated in vacuo and the residue purified by pre-packed silica cartridge eluting with ethyl acetate-cyclohexane (0-50%). The relevant fractions were evaporated to give the title product, 8.7 mg. LCMS [LCMS1] Rt 1.48 min, m/z (ES+) 476 (M+H).

Provenance & Evidence