反应详情

温度

50 °C

To a solution of N-(2,4-dimethylphenyl)-3,5-difluoro-N-isobutyl-4-(oxiran-2-yl)benzenesulfonamide (150 mg, 0.379 mmol) in ethanol (1.5 mL) at 25° C. was added morpholine (0.033 ml, 0.379 mmol) and the reaction mixture stirred at 50° C. for 6 hours. The mixture was concentrated in vacuo and purified by mass directed autoprep (ammonium carbonate modifier). The appropriate fractions were combined and evaporated in vacuo to give the required product, 9 mg, as a colourless oil. LCMS [LCMS2] Rt 1.33 min, m/z (ES+) 483 (M+H).

1. concentrationThe mixture was concentrated in vacuo
2. custompurified by mass
3. customevaporated in vacuo