Potassium Hydroxide → HCID 89876014, compound

Participants

Reaction Conditions

Reaction Steps

3-chloro-N-(2,4-dimethylphenyl)-N-isobutyl-4-vinylbenzenesulfonamide (250 mg, 0.662 mmol), tris(dibenzylideneacetone)dipalladium(0) (6.06 mg, 6.62 μmol), 2-di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl (2.81 mg, 6.62 μmol) and potassium hydroxide (111 mg, 1.985 mmol) were added to a microwave vial. 1,4-dioxane (1 mL) and water (1.000 mL) were then added. The reaction vessel was sealed and heated by microwaves (Biotage Initiator) to 150° C. for 2 hours. LCMS analysis showed the desired product and several side-products. The crude material was purified by silica (Si) chromatography (0-100% ethyl acetate-cyclohexane gradient). The appropriate fractions were combined and evaporated in vacuo to give the required product, 100.8 mg, as a yellow gum. LCMS [LCMS2] Rt 1.42 min, m/z (ES+) 360 (M+H).

Provenance & Evidence