m-Chloroperbenzoic acid → HCID 89876041, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-(2,4-dimethylphenyl)-3-hydroxy-N-isobutyl-4-vinylbenzenesulfonamide (100.8 mg, 0.280 mmol) in dichloromethane (DCM) (20 mL) stirred under nitrogen at 0° C. was added meta-chloroperoxybenzoic acid (mCPBA) (194 mg, 1.122 mmol) portionwise. The reaction mixture was stirred at 0° C. for 30 minutes, then for 72 hours at room temperature. DCM (20 mL) was added to the mixture and the organic phase washed with water (20 mL), dried using a hydrophobic frit and concentrated under a stream of nitrogen to give the crude product, 60 mg, which was used directly in the next step with no further purification. LCMS [LCMS2] Rt 1.42 min, m/z (ES−) 374 (M−H).

Provenance & Evidence