Morpholine → HCID 72188990, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of N-(2,4-dimethylphenyl)-3-hydroxy-N-isobutyl-4-(oxiran-2-yl)benzenesulfonamide (60 mg, 0.160 mmol) in ethanol (1 mL) at 25° C. was added morpholine (30.6 mg, 0.352 mmol) and the reaction mixture stirring at 50° C. for 12 hours. The reaction mixture was then concentrated in vacuo and purified by mass directed autoprep (ammonium carbonate modifier). The relevant fractions were concentrated under a stream of nitrogen to give a single regioisomer of the desired product, 11.2 mg. LCMS [LCMS2] Rt 1.25 min, m/z (ES+) 463 (M+H).

Provenance & Evidence