反应详情

温度

20 °C

To a solution of (2,4-dimethylphenyl)(2-methylpropyl)amine (400 mg, 2.256 mmol) in pyridine (5 mL) stirred in air at room temperature was added 4-formylbenzene-1-sulfonyl chloride (760 mg, 3.71 mmol) in one charge. The reaction mixture was stirred at 20° C. for 30 minutes and then stood for 6 hours. The solvent was evaporated in vacuo (Vaportec V10) to give the crude product. The crude was purified by silica (Si) chromatography (0-25% ethyl acetate-cyclohexane). The appropriate fractions were combined and evaporated in vacuo to give the required product, 794 mg as a colourless gum. LCMS [LCMS1] Rt 1.33 min, m/z (ES+) 346 (M+H).

1. additioncharge
2. waitstood for 6 hours
3. customThe solvent was evaporated in vacuo (Vaportec V10)
4. customto give the crude product
5. customThe crude was purified by silica (Si) chromatography (0-25% ethyl acetate-cyclohexane)
6. customevaporated in vacuo