4-ethyl-N-(2-methylpropyl)aniline → methyl 2-bromo-5-(N-(4-ethylphenyl)-N-isobutylsulfamoyl)benzoate

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-ethyl-N-isobutylaniline (400 mg, 2.256 mmol) in pyridine (2 mL) stirred in air at 20° C. was added methyl 2-bromo-5-(chlorosulfonyl)benzoate (707 mg, 2.256 mmol) portionwise, over 30 minutes. The reaction mixture was stirred at 20° C. for 30 minutes, then left to stand overnight. The solvent was evaporated in vacuo to give the crude product as a sticky yellow solid. This was triturated with methanol and filtered and dried to give the desired product as a white solid, 600 mg. LCMS [LCMS1] Rt 1.41 min, m/z (ES+) 454/456 (M+H).

Provenance & Evidence