Sulfuric Acid → HCID 89876280, compound

Participants

Reaction Steps

A mixture of methyl 5-(N-(4-ethylphenyl)-N-isobutylsulfamoyl)-2-((trimethylsilyl)ethynyl)benzoate (320 mg, 0.678 mmol), mercuric sulphate (201 mg, 0.678 mmol), H2SO4 (1.357 mL, 1.357 mmol) and acetone (6 mL) was heated at reflux for 4 hours. The mixture was partitioned between ammonium chloride solution (10%, 20 mL) and dichloromethane (DCM) (2×25 mL) then organics separated, dried (MgSO4) and evaporated onto florisil. The crude material was purified by silica (Si) chromatography (0-100% dichloromethane-cyclohexane gradient) to give the title compound as a colourless gum, 110 mg. LCMS [LCMS1] Rt 1.33 min, m/z (ES+) 418 (M+H).

Provenance & Evidence