Methyl 5-(chlorosulfonyl)-2-hydroxybenzoate → methyl 5-(N-(4-ethylphenyl)-N-isobutylsulfamoyl)-2-hydroxybenzoate

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-ethyl-N-isobutylaniline (598 mg, 3.37 mmol) in pyridine (10 mL) stirred in air at 20° C., was added methyl 5-(chlorosulfonyl)-2-hydroxybenzoate (845 mg, 3.37 mmol) portionwise, over 1 hour. The reaction mixture was then stirred at 20° C. for 30 minutes. The solvent was evaporated in vacuo to give the crude product as a yellow sticky solid. This was triturated with methanol then filtered and dried to give the title product as a white solid, 907 mg. LCMS [LCMS1] Rt 1.38 min, m/z (ES+) 392 (M+H).

Provenance & Evidence