HCID 89815531, compound → HCID 89828070, compound

HRID 1487143Notes

Reaction equation

HRID 1487143 reaction equation
[OH:1][CH2:2][C:3]1([NH:6][C:7](=[O:17])[C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-])=O)[CH:9]=2)[CH2:5][CH2:4]1>CO.[Pd]>[NH2:14][C:10]1[CH:9]=[C:8]([CH:13]=[CH:12][CH:11]=1)[C:7]([NH:6][C:3]1([CH2:2][OH:1])[CH2:4][CH2:5]1)=[O:17]

Participants

3

Reactant 1

HCID 89815531HCID 89815531, compound

Product 1

HCID 89828070HCID 89828070, compound

Reagents, catalysts & solvents 1

HCID 86643649HCID 86643649, compoundSolvent

Procedure

To the solution of N-(1-(hydroxymethyl)cyclopropyl)-3-nitrobenzamide (0.135 g, 0.571 mmol) in methanol Pd—C (50% wet) (0.015 g) was added and stirred at room temperature under hydrogen for 2 hr. Reaction mixture was filtered through celite and concentrated to afford product (01 g, 85%).

Workup

  1. customReaction mixture
  2. filtrationwas filtered through celite
  3. concentrationconcentrated
  4. customto afford product (01 g, 85%)

Sources & evidence

ORD record
ord-21d788caf814486da9cdfbc84e33beb0
Source dataset
uspto-grants-2016_08
Patent number
US09428499B2

Reaction notes

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