(S)-1,1-dibenzyl 2-ethyl propane-1,1,2-tricarboxylate → (S)-2-(1-ethoxy-1-oxopropan-2-yl)malonic acid

Participants

Reaction Steps

To the solution of (S)-1,1-dibenzyl 2-ethyl propane-1,1,2-tricarboxylate (23 g, 0.06 mol) in methanol (500 mL) was added palladium on carbon (10%, 2 g), and then the mixture was stirred under an atmosphere of hydrogen at room temperature overnight. The catalyst was filtrated and the filtrate was concentrated under reduced pressure to afford the crude product (S)-2-(1-ethoxy-1-oxopropan-2-yl)malonic acid, which was purified by silica gel chromatography (10 g, yield 83%).

Provenance & Evidence