Methanol → HCID 86699675, compound

Participants

Reaction Steps

To a solution of 2,4-dichloro-7-(4-methoxybenzyl)-5,5-dimethyl-5H-pyrrolo[2,3-d]pyrimidin-6(7H)-one (270 mg, 0.77 mol) in tetrahydrofuran (10 mL) was added diborane (1 M in tetrahydrofuran, 3.85 mL, 3.85 mmol) dropwise under nitrogen. The mixture was refluxed overnight. After cooling, methanol (2 mL) was added dropwise to decompose the excessive diborane. The solvent was removed and the residue was purified by silica gel column chromatography to afford the product

Provenance & Evidence