HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1487180Generated: November 2, 2026
Water → (R)-1,1-dibenzyl 2-ethyl propane-1,1,2-tricarboxylate
https://huagongshe.com/reaction/1487180
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | Dibenzyl malonate | HCID 84754 | — |
| Reactant | Propanoic acid, 2-[(methylsulfonyl)oxy]-, ethyl ester, (R)- | HCID 2723759 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (R)-1,1-dibenzyl 2-ethyl propane-1,1,2-tricarboxylate | HCID 86699677 | — |
Reaction Steps
To a solution of (R)-ethyl 2-(methylsulfonyloxy)propanoate (15 g, 0.076 mol) in DMF (300 ml) was added dibenzyl malonate (21.5 g, 0.076 mol) and CsF (11.5 g, 0.076 mol). The mixture was heated to 50° C. for 2 days. After cooled to room temperature, the mixture was poured into water and then extracted with EtOAc. The organic phase was washed with brine, water and dried. Concentrated to afford (R)-1,1-dibenzyl 2-ethyl propane-1,1,2-tricarboxylate, which was purified by silica gel chromatography (11 g, 40%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09428508B2 |
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| Source dataset | uspto-grants-2016_08 |
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| ORD ID | ord-bba6c303198442ecaa2fde33d15cd605 |
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| Source note | uspto-grants-2016_08 |
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