反应详情

To the solution of (R)-1,1-dibenzyl 2-ethyl propane-1,1,2-tricarboxylate (11 g, 0.029 mol) in MeOH (500 ml) was added Pd/C (wet, 2 g), and then the mixture was stirred under hydrogen atmosphere at room temperature overnight. After filtered the Pd/C, the solvent was removed under reduced pressure to afford (R)-2-(1-ethoxy-1-oxopropan-2-yl)malonic acid, which was purified by silica gel chromatography (3.5 g, 60%).

1. filtrationAfter filtered the Pd/C
2. customthe solvent was removed under reduced pressure