Triethylamine → HCID 86699680, compound

Participants

Reaction Steps

(R)-2,4-dichloro-7-(4-methoxybenzyl)-5-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine was prepared from (R)-2-(2,4,6-trichloropyrimidin-5-yl)propyl methanesulfonate (60 mg, 0.188 mmol), (4-methoxyphenyl)methanamine (39 mg, 0.28 mmol) and triethyl amine (38 mg, 0.375 mmol), and isolated as a yellow (45 mg, yield 74%). 1H NMR (400 MHz, CDCl3) δ ppm 7.16-7.19 (d, 2H, J=8.8 Hz), 6.86-6.88 (d, 2H, J=8.4 Hz), 4.54 (s, 2H), 3.80 (s, 3H), 3.66-3.71 (t, 1H, J=6.0 Hz), 3.33-3.36 (m, 1H), 3.08-3.12 (dd, 1H, J=4.4 Hz, 10.0 Hz), 1.29-1.31 (d, 3H, J=6.8 Hz).

Provenance & Evidence