Urea → HCID 68283940, compound

Participants

Reaction Steps

To a solution of anhydrous ethanol (1500 mL) was added sodium (25.2 g, 1.1 mol) in pieces. After all the sodium dissolved, triethyl ethane-1,1,2-tricarboxylate (180.0 g, 733 mmol) and urea (43.9 g, 733 mmol) was added respectively. The reaction mixture was heated at reflux overnight and cooled to room temperature, evaporated to dryness. The residue was diluted with water and acidified by diluted hydrochloric acid (2 N). The mixture was evaporated and purified by silica gel chromatography to afford the product ethyl 2-(2,4,6-trioxohexahydropyrimidin-5-yl)acetate as a pale-yellow solid (82.8 g, yield 35.0%).

Provenance & Evidence