5-nitro-2,3-dihydro-1H-isoindol-1-one → 5-Amino-2,3-dihydro-isoindol-1-one

Participants

Reaction Steps

To a solution of 5-nitroisoindolin-1-one (60 mg, 0.337 mmol) in methanol (20 mL) was added palladium on carbon (10%, 50 mg). The mixture was stirred under an atmosphere of hydrogen for 1 hour. Filtration through Celite, followed by concentration led to 5-aminoisoindolin-1-one as a tan solid (38 mg, yield 76.2%).

Provenance & Evidence