HCID 86699689, compound → HCID 68284027, compound

Participants

Reaction Steps

To a solution of crude 4-(3-(4-nitro-1H-indol-1-yl)propyl)morpholine in methanol (100 mL) was added palladium on carbon (10%). The mixture was stirred under an atmosphere of hydrogen for 12 hours. The catalyst was removed by filtration and the filtrate was evaporated. The residue was purified by silica gel chromatography to afford the product 1-(3-morpholinopropyl)-1H-indol-4-amine (5 g, yield 67%, two steps) as a brown solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.12, J=2.4 Hz).

Provenance & Evidence