1-Ethyl-4-(pent-4-ynyl)piperazine → 5-((Benzyloxy)methyl)-2-butyl-7-(5-(4-ethylpiperazin-1-yl)pent-1-yn-1-yl)-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-amine

Participants

Role	Name	HCID	Charge
Reactant	1-Ethyl-4-(pent-4-ynyl)piperazine	HCID 86608220	—
Reactant	5-((Benzyloxy)methyl)-2-butyl-7-iodo-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-amine	HCID 118416653	—
Reactant	HCID 118453797	HCID 118453797	—
Product	5-((Benzyloxy)methyl)-2-butyl-7-(5-(4-ethylpiperazin-1-yl)pent-1-yn-1-yl)-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-amine	HCID 118453793	—

Reaction Steps

Prepared similarly to Intermediate 17 from 5-((benzyloxy)methyl)-2-butyl-7-iodo-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-amine and 1-ethyl-4-(pent-4-yn-1-yl)piperazine (Bioorg. Med. Chem. Lett. 2011, 21(6), 1601; WO2006/105372).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09428512B2
Source dataset	uspto-grants-2016_08
ORD ID	ord-c2ab52edf15b47009caa38f35e6a10ed
Source note	uspto-grants-2016_08