反应详情

To a solution of 5-((benzyloxy)methyl)-2-butyl-7-(3-(piperazin-1-yl)prop-1-yn-1-yl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine (38 mg, 0.088 mmol) in anhydrous N,N-dimethylformamide (1 mL) at room temperature was added triethylamine (25 μL, 0.179 mmol) and iodoethane (10 μL, 0.125 mmol). The reaction was stirred at room temperature for 5 hours. The reaction was evaporated in vacuo to yield a pale yellow oil. The oil was dissolved in MeOH:DMSO (1:1) (1 mL) and purified by MDAP (Method B). The appropriate fraction was evaporated in vacuo to yield the title compound as a pale yellow oil (28 mg).

1. customThe reaction was evaporated in vacuo
2. customto yield a pale yellow oil
3. custompurified by MDAP (Method B)
4. customThe appropriate fraction was evaporated in vacuo