HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1487268Generated: November 1, 2026
Trimethyl orthoacetate → HCID 86719150, compound
https://huagongshe.com/reaction/1487268
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethyl orthoacetate | HCID 15050 | — |
| Reactant | 5-Bromo-3-chloro-2-hydrazinylpyrazine | HCID 58446977 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 86719150 | HCID 86719150 | — |
Reaction Steps
5-bromo-3-chloro-2-hydrazinylpyrazine 11-1 (945 mg; 3.51 mmol) is dissolved in 12 ml trimethyl orthoacetate and heated up to 130° C. for 1 hour. The solution is diluted with water and extracted with EtOAc. The organic phase is then purified with flash chromatography: cHex/EtOAc=70%/30% to 55%/45% within 10 column volumes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09428513B2 |
|---|
| Source dataset | uspto-grants-2016_08 |
|---|
| ORD ID | ord-08adea3c23744d35b59c7fcf8450bb92 |
|---|
| Source note | uspto-grants-2016_08 |
|---|
