2-Methoxyethylamine → HCID 118063410, compound

Participants

Reaction Conditions

Reaction Steps

2,4-Dichloro-5-nitro-pyridine (500 mg; 2.46 mmol), 2-methoxyethylamine (225 n1; 2.46 mmol) and triethylamine (400 μl; 2.82 mmol) are suspended in 2.5 ml NMP and stirred for 1 h at 25° C. To this suspension morpholine (500 μl; 5.71 mmol) is added and the resulting mixture is stirred for 16 h at 50° C. The crude intermediate is purified using reversed phase chromatography (prep. HPLC1). This intermediate is dissolved in 30 ml THF and palladium on carbon is added. The reaction mixture is stirred for 3 h at 25° C. and 4 bar hydrogen pressure. The solid material is filtered off and the solvent is evaporated.

Provenance & Evidence