反应详情

温度

100 °C

1,5-Dimethyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester C-1 (2.60 g; 14.35 mmol) is suspended in MeOH. Sodium hydroxide (1 M solution, 45 ml; 45.00 mmol) is added and the reaction mixture is heated up to 100° C. (Drysyn, reflux) for 2 h. MeOH is removed under reduced pressure and 1N HCl (46 ml) is added to the solution, precipitation occurs. The precipitate is filtered off and dried under reduced pressure.

1. temperature(Drysyn, reflux) for 2 h
2. customMeOH is removed under reduced pressure and 1N HCl (46 ml)
3. additionis added to the solution, precipitation
4. filtrationThe precipitate is filtered off
5. customdried under reduced pressure