HCID 118509533, compound → HCID 118500168, compound

HRID 1487275Notes

Reaction equation

HRID 1487275 reaction equation
[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([NH:22][C:23]([C:25]3[CH:30]=[C:29]([CH3:31])[C:28](=[O:32])[N:27]([CH3:33])[CH:26]=3)=O)=[C:10]([NH:13][C@H:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH3:15])[CH:11]=2)[C:6]([CH3:35])([CH3:34])[C:5]1=[O:36])([CH3:3])[CH3:2]>C(O)(=O)C>[CH3:33][N:27]1[C:28](=[O:32])[C:29]([CH3:31])=[CH:30][C:25]([C:23]2[N:13]([C@H:14]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH3:15])[C:10]3[C:9]([N:22]=2)=[CH:8][C:7]2[C:6]([CH3:35])([CH3:34])[C:5](=[O:36])[N:4]([CH:1]([CH3:3])[CH3:2])[C:12]=2[CH:11]=3)=[CH:26]1

Participants

3

Reactant 1

HCID 118509533HCID 118509533, compound

Product 1

HCID 118500168HCID 118500168, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
120 °C

Procedure

1,5-Dimethyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid [1-isopropyl-3,3-dimethyl-2-oxo-6-((S)-1-phenyl-ethylamino)-2,3-dihydro-1H-indol-5-yl]-amide I-2′ (100 mg; 0.21 mmol) is dissolved in 2 ml acetic acid and stirred at 120° C. for 7 h. The solvent is evaporated and the crude product is purified using reversed phase chromatography (Method: prep. HPLC2).

Workup

  1. customThe solvent is evaporated
  2. customthe crude product is purified

Sources & evidence

ORD record
ord-430ed3e8b3fb4e36a9750e30122da9a3
Source dataset
uspto-grants-2016_08
Patent number
US09428515B2

Reaction notes

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