Trifluoroacetic acid → Trifluoroacetic acid

Participants

Reaction Steps

A solution of (3S,4S)-tert-butyl 3-((7-carbamoyl-2-(1-ethyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-8-yl)amino)-4-(fluoromethyl)pyrrolidine-1-carboxylate (15 mg, 0.032 mmol) in DCM (0.5 ml) was treated with TFA (0.024 ml, 0.317 mmol) at room temperature for 2 h. The reaction mixture was concentrated to give 2-(1-ethyl-1H-pyrazol-4-yl)-8-(((3S,4S)-4-(fluoromethyl)pyrrolidin-3-yl)amino)imidazo[1,2-b]pyridazine-7-carboxamide, 2 TFA (15.1 mg, 0.025 mmol, 79% yield) as a white solid. ESI-MS (Method A): m/z 373.3 ([M+H]+).

Provenance & Evidence