1-Cyanocyclopropanecarboxylic acid → HCID 118253709, compound

Participants

Reaction Steps

According to the procedure described for Example 56, Example 57 was prepared from (3S,4S)-tert-butyl 3-((2-bromo-7-carbamoylimidazo[1,2-b]pyridazin-8-yl)amino)-4-(fluoromethyl)pyrrolidine-1-carboxylate (from Step 2 of Example 56) via Suzuki coupling reaction with 1-ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole under conditions similar to Step 3 of Example 56, deprotection of N-Boc under conditions similar to Step 3 of Example 56 and amidation with 1-cyanocyclopropanecarboxylic acid under conditions similar to Step 5 of Example 56.

Provenance & Evidence