Acetonitrile → Leflunomide

HRID 148738Notes

Reaction equation

HRID 148738 reaction equation
[CH3:1][c:2]1[c:3]([C:7](=[O:8])[Cl:9])[cH:4][n:5][o:6]1.[CH3:21][C:22]#[N:23].[F:10][C:11]([c:12]1[cH:13][cH:14][c:15]([NH2:16])[cH:17][cH:18]1)([F:19])[F:20]>>[CH3:1][c:2]1[c:3]([C:7](=[O:8])[NH:16][c:15]2[cH:14][cH:13][c:12]([C:11]([F:10])([F:19])[F:20])[cH:18][cH:17]2)[cH:4][n:5][o:6]1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 99644-(Trifluoromethyl)anilineHCID 27599175-Methyl-1,2-oxazole-4-carbonyl chloride

Product 1

HCID 3899Leflunomide

Sources & evidence

ORD record
ord-29b117a9f8c940dfb641b5df23d2cf52
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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