Methyl iodide → HCID 68276402, compound

HRID 1487399Notes

Reaction equation

HRID 1487399 reaction equation
[I:1][CH3:2].[N+:3]([C:6]1[CH:18]=[C:17]([C:19]2[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=2)[CH:16]=[CH:15][C:7]=1[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])([O-:5])=[O:4]>CC(C)=O>[I-:1].[C:11]([O:10][C:8]([C:7]1[CH:15]=[CH:16][C:17]([C:19]2[CH:24]=[CH:23][N+:22]([CH3:2])=[CH:21][CH:20]=2)=[CH:18][C:6]=1[N+:3]([O-:5])=[O:4])=[O:9])([CH3:14])([CH3:13])[CH3:12]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 68276348HCID 68276348, compound

Product 1

HCID 68276402HCID 68276402, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
60 °C

Procedure

7.55 mL of iodomethane (121 mmol) is added to a solution of 16.2 g of tert-butyl 2-nitro-4-(pyridin-4-yl)benzoate (60.6 mmol) in 20 mL of acetone. The reaction medium is heated at 60° C. for 4 hours and then at room temperature overnight. After dry concentration, 27 g of orange crystals are isolated (100%).

Workup

  1. customat room temperature
  2. customovernight
  3. customAfter dry
  4. concentrationconcentration, 27 g of orange crystals
  5. customare isolated (100%)

Sources & evidence

ORD record
ord-d3b5aae711b2410b8e642b55130b3303
Source dataset
uspto-grants-2016_08
Patent number
US09428510B2

Reaction notes

Loading…