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HRID 1487453作成日：2026年10月26日

6-(Hydroxymethyl)pyridine-3-boronic acid → 2,2-dichloro-1-((4S,5R)-4-(fluoromethyl)-5-(4-(6-(hydroxymethyl)pyridin-3-yl)phenyl)-2,2-dimethyloxazolidin-3-yl)ethanone

https://huagongshe.com/reaction/1487453

反応式

関与物質

役割名称HCID仕込み量
反応物6-(Hydroxymethyl)pyridine-3-boronic acidHCID 44118255—
反応物(4S,5R)-3-(dichloroacetyl)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyl-1,3-oxazolidineHCID 86695394—
生成物2,2-dichloro-1-((4S,5R)-4-(fluoromethyl)-5-(4-(6-(hydroxymethyl)pyridin-3-yl)phenyl)-2,2-dimethyloxazolidin-3-yl)ethanoneHCID 86695406—

反応手順

Following the general procedure of Example 1—Step 1 and making non-critical variations but using 2,2-dichloro-1-((4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidin-3-yl)ethanone and (6-(hydroxymethyl)pyridin-3-yl)boronic acid as starting materials the title compound is obtained (800 mg): m/z (CI) M−H 426.1.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09428528B2
出典データセットuspto-grants-2016_08
ORD IDord-6b2075fe9d2c49218f7c73871f51afde
出典メモuspto-grants-2016_08