Trifluoroacetic acid → HCID 131733108, compound

Participants

Reaction Steps

To a solution of (4R,5R)-4-Fluoromethyl-5-{4-[6-(isopropyl amino-methyl)-pyridin-3-yl]-phenyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (100 mg, 0.218 mmol) in CH2Cl2 (0.17 mL) is added trifluoroacetic acid (0.4 mL) at 0° C. Reaction mixture is allowed to stir at room temperature for 2 hours. The volatiles are removed under reduced pressure and crude material is purified by column chromatography over basic alumina using 50% methanol in CH2Cl2 as eluent to afford title compound (70 mg, impure). LC-MS (m/z): [M+H]=318.2.

Provenance & Evidence