Cesium carbonate → HCID 86726496, compound

Participants

Reaction Conditions

Reaction Steps

To a degassed mixture of 2-chloro-4-cyclopentyloxy-5-(2-methyl-benzooxazol-6-yl)-7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine (1 equiv), (R)-(4-amino-3-methoxyphenyl)(2-methylaziridin-1-yl)methanone (1.2 equiv) and cesium carbonate (2 equiv) in 1,4-dioxane (0.05M) were added palladium acetate (0.2 equiv) and 2,2′-bis-diphenylphosphanyl-[1,1′]binaphthalenyl (0.4 equiv). The reaction mixture was refluxed at 110° C. for 1 h. The reaction mixture was filtered, concentrated under reduced pressure, and the crude product was purified by preparative thin layer chromatography (5% MeOH in DCM) to afford the desired product (75% yield). MS (ESI) m/z 669.1 [M+H]+.

Provenance & Evidence