HCID 178494664, compound → HCID 178425805, compound

HRID 1487861Notes

Reaction equation

HRID 1487861 reaction equation
C[O:2][CH2:3][C:4]1[NH:5][C:6]([C:10]2[CH:11]=[C:12]([CH:29]=[CH:30][C:31]=2[CH3:32])[C:13]([N:15]2[CH2:20][CH2:19][CH:18]([C:21]3[CH:28]=[CH:27][C:24]([C:25]#[N:26])=[CH:23][CH:22]=3)[CH2:17][CH2:16]2)=[O:14])=[C:7]([CH3:9])[N:8]=1.COCC1NC(C2C(C)=CC(C)=C(C=2)C(N2CCC(C3C=CC(C#N)=CC=3)CC2)=O)=C(C)N=1>>[OH:2][CH2:3][C:4]1[NH:5][C:6]([C:10]2[CH:11]=[C:12]([CH:29]=[CH:30][C:31]=2[CH3:32])[C:13]([N:15]2[CH2:16][CH2:17][CH:18]([C:21]3[CH:22]=[CH:23][C:24]([C:25]#[N:26])=[CH:27][CH:28]=3)[CH2:19][CH2:20]2)=[O:14])=[C:7]([CH3:9])[N:8]=1

Participants

3

Reactant 2

HCID 178494664HCID 178494664, compound2×HCID 178494665HCID 178494665, compound2×

Product 1

HCID 178425805HCID 178425805, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 3, except 4-(1-(3-(2-(methoxymethyl)-4-methyl-1H-imidazol-5-yl)-4-methylbenzoyl)piperidin-4-yl)benzonitrile (compound 11) was used in place of 4414542-(methoxymethyl)-4-methyl-1H-imidazol-5-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile (compound 2). m/z (ES+) 415 (M+H)+.

Sources & evidence

ORD record
ord-4da45368378349dc937569de6a5a0c52
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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