反应详情

Into a 25-mL round-bottom flask, was placed a mixture of 2-methyl-1H-imidazole-4-carbonitrile (compound 16.3, 50 mg, 0.47 mmol), N-iodosuccinimide (116 mg, 0.52 mmol) in ACN (5 mL). The resulting solution was heated at reflux overnight, then cooled to room temperature and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with ethyl acetate/petroleum ether (1/2) to yield 60 mg (55%) of the title compound as a light yellow solid.

1. customInto a 25-mL round-bottom flask, was placed
2. temperatureThe resulting solution was heated
3. temperatureat reflux overnight
4. concentrationconcentrated under reduced pressure
5. customThe residue was purified by silica gel column chromatography with ethyl acetate/petroleum ether (1/2)