3-Bromo-4-methylbenzoic acid → HCID 82052200, compound

HRID 1487866Notes

Reaction equation

HRID 1487866 reaction equation
[CH:1]1([C:4]2[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][C:5]=2[C:13](=[O:16])[CH2:14][CH3:15])CC1.Br[C:18]1C=C(C=CC=1C)C(O)=O.BrC1C=C(C=CC=1C1CC1)C(O)=O.C([Mg]Br)CC>>[C:13]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:4]=1[CH3:1])[C:8]([OH:10])=[O:9])(=[O:16])[CH2:14][CH2:15][CH3:18]

Participants

5

Reactant 4

HCID 821303-Bromo-4-methylbenzoic acidHCID 448285263-Bromo-4-cyclopropylbenzoic acidHCID 90021739HCID 90021739, compoundHCID 178455851HCID 178455851, compound

Product 1

HCID 82052200HCID 82052200, compound

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 10.6, except 3-bromo-4-methylbenzoic acid was used in place of 3-bromo-4-cyclopropylbenzoic acid (compound 10.3) and propylmagnesium bromide was used in place of ethylmagnesium bromide.

Sources & evidence

ORD record
ord-4f6329be2b3e457fb5c6c0cef779ee06
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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