6-Bromo-[1,2,4]triazolo[4,3-a]pyridine → tert-Butyl 4-([1,2,4]triazolo[4,3-a]pyridin-6-yl)piperidine-1-carboxylate

HRID 1487886Notes

Reaction equation

HRID 1487886 reaction equation
C([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)=[CH:5]C=1)#N.BrC1C=CC2[N:27]([CH:29]=[N:30][N:31]=2)C=1>>[N:31]1[N:30]=[CH:29][N:27]2[CH:5]=[C:6]([CH:9]3[CH2:10][CH2:11][N:12]([C:15]([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:16])[CH2:13][CH2:14]3)[CH:7]=[CH:8][C:3]=12

Participants

3

Reactant 2

HCID 177500186-Bromo-[1,2,4]triazolo[4,3-a]pyridineHCID 22492960Tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate

Product 1

HCID 90033778tert-Butyl 4-([1,2,4]triazolo[4,3-a]pyridin-6-yl)piperidine-1-carboxylate

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 1.1, except 6-bromo-[1,2,4]triazolo[4,3-a]pyridine was used in place of 4-bromobenzonitrile. m/z (ES+) 303 (M+H)+.

Sources & evidence

ORD record
ord-deb0f06ea28c48709b8586ef617d8ecb
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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