6-(Piperidin-4-yl)-[1,2,4]triazolo[4,3-a]pyridine → 5-(Piperidin-4-yl)-[1,2,3]triazolo[1,5-a]pyridine

HRID 1487894Notes

Reaction equation

HRID 1487894 reaction equation
N1CCC(C2C=CC3N(C=NN=3)C=2)CC1.[N:16]1[N:20]2[CH:21]=[CH:22][C:23]([CH:25]3[CH2:30][CH2:29][N:28](C(OC(C)(C)C)=O)[CH2:27][CH2:26]3)=[CH:24][C:19]2=[CH:18][N:17]=1.N1N=CN2C=C(C3CCN(C(OC(C)(C)C)=O)CC3)C=CC=12>>[NH:28]1[CH2:27][CH2:26][CH:25]([C:23]2[CH:22]=[CH:21][N:20]3[N:16]=[N:17][CH:18]=[C:19]3[CH:24]=2)[CH2:30][CH2:29]1

Participants

4

Reactant 3

HCID 596274706-(Piperidin-4-yl)-[1,2,4]triazolo[4,3-a]pyridineHCID 90033778tert-Butyl 4-([1,2,4]triazolo[4,3-a]pyridin-6-yl)piperidine-1-carboxylateHCID 90066690Tert-butyl 4-([1,2,3]triazolo[1,5-a]pyridin-5-yl)piperidine-1-carboxylate2×

Product 1

HCID 900293095-(Piperidin-4-yl)-[1,2,3]triazolo[1,5-a]pyridine

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 36.2, except tert-butyl 4-([1,2,3]triazolo[1,5-a]pyridin-5-yl)piperidine-1-carboxylate (compound 40.3) was used in place of tert-butyl 4-([1,2,4]triazolo[4,3-a]pyridin-6-yl)piperidine-1-carboxylate (compound 36.1). m/z (ES+) 203(M+H)+.

Sources & evidence

ORD record
ord-f54996375fa94b11b4c8dcbfbffe4740
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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