Formic Acid → 7-Bromo-[1,2,4]triazolo[4,3-a]pyridine

Temperature

100 °C

4-Bromo-2-hydrazinylpyridine (compound 41.1) was suspended in formic acid (3 mL). The mixture was heated at 100° C. for one hour, then upon complete reaction, the mixture cooled to room temperature. The volatile organics were removed under reduced pressure, then water (50 mL) was added to the residue. The solids that formed were filtered, washed with water and dried under reduced pressure at 50° C. to give 1.68 g (90%) of the title compound as an off-white solid. m/z (ES+) 198, 200 (M+H)+.

1. customupon complete reaction
2. temperaturethe mixture cooled to room temperature
3. customThe volatile organics were removed under reduced pressure
4. additionwater (50 mL) was added to the residue
5. customThe solids that formed
6. filtrationwere filtered
7. washwashed with water
8. customdried under reduced pressure at 50° C.

ORD record

ord-1368ebcab7934dd9aa7e60d567f1e4dd

Source dataset

uspto-grants-2016_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09428502B2