6-(Piperidin-4-yl)-[1,2,4]triazolo[4,3-a]pyridine → 7-(Piperidin-4-yl)-[1,2,4]triazolo[4,3-a]pyridine

HRID 1487898Notes

Reaction equation

HRID 1487898 reaction equation
N1CCC(C2C=CC3N(C=NN=3)C=2)CC1.[N:16]1[N:17]=[CH:18][N:19]2[CH:24]=[CH:23][C:22]([CH:25]3[CH2:30][CH2:29][N:28](C(OC(C)(C)C)=O)[CH2:27][CH2:26]3)=[CH:21][C:20]=12.N1N=CN2C=C(C3CCN(C(OC(C)(C)C)=O)CC3)C=CC=12>>[NH:28]1[CH2:27][CH2:26][CH:25]([C:22]2[CH:23]=[CH:24][N:19]3[CH:18]=[N:17][N:16]=[C:20]3[CH:21]=2)[CH2:30][CH2:29]1

Participants

4

Reactant 3

HCID 596274706-(Piperidin-4-yl)-[1,2,4]triazolo[4,3-a]pyridineHCID 90033778tert-Butyl 4-([1,2,4]triazolo[4,3-a]pyridin-6-yl)piperidine-1-carboxylateHCID 90066679Tert-butyl 4-([1,2,4]triazolo[4,3-a]pyridin-7-yl)piperidine-1-carboxylate2×

Product 1

HCID 596274767-(Piperidin-4-yl)-[1,2,4]triazolo[4,3-a]pyridine

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 36.2, except tert-butyl 4-([1,2,4]triazolo[4,3-a]pyridin-7-yl)piperidine-1-carboxylate (compound 41.3) was used in place of tert-butyl 4-([1,2,4]thazolo[4,3-a]pyridin-6-yl)piperidine-1-carboxylate (compound 36.1) m/z (ES+) 203 (M+H)+.

Sources & evidence

ORD record
ord-eb2b96d729554ce1b846748efe3d45df
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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