N-((4-bromopyridin-2-yl)methyl)formamide → 3-Methyl-7-(piperidin-4-yl)imidazo[1,5-a]pyridine hydrochloride

HRID 1487933Notes

Reaction equation

HRID 1487933 reaction equation
[ClH:1].[NH:2]1[CH2:7][CH2:6][CH:5]([C:8]2[CH:13]=[CH:12][N:11]3[CH:14]=[N:15][CH:16]=[C:10]3[CH:9]=2)[CH2:4][CH2:3]1.Br[C:18]1C=CN=C(CNC(=O)C)C=1.BrC1C=CN=C(CNC=O)C=1>>[ClH:1].[CH3:18][C:14]1[N:11]2[CH:12]=[CH:13][C:8]([CH:5]3[CH2:4][CH2:3][NH:2][CH2:7][CH2:6]3)=[CH:9][C:10]2=[CH:16][N:15]=1

Participants

4

Reactant 3

HCID 86071649N-((4-bromopyridin-2-yl)methyl)formamideHCID 90021325N-((4-Bromopyridin-2-yl)methyl)acetamide2×HCID 900290287-(Piperidin-4-yl)imidazo[1,5-a]pyridine hydrochloride

Product 1

HCID 900307823-Methyl-7-(piperidin-4-yl)imidazo[1,5-a]pyridine hydrochloride

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 39.5, except N-((4-bromopyridin-2-yl)methyl)acetamide (compound 67.1) was used in place of N-((4-bromopyridin-2-yl)methyl)formamide (compound 39.2).

Sources & evidence

ORD record
ord-a188bedc4dba4d7bbb54a7e30a8781ed
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

Loading…