4-Chlorophenylboronic acid → 3-(4-Chlorophenyl)azetidine--hydrogen chloride (1/1)

HRID 1487963Notes

Reaction equation

HRID 1487963 reaction equation
[ClH:1].[NH:2]1[CH2:5][CH:4]([C:6]2[CH:13]=[CH:12][C:9](C#N)=[CH:8][CH:7]=2)[CH2:3]1.[Cl:14]C1C=CC(B(O)O)=CC=1>>[ClH:14].[Cl:1][C:9]1[CH:12]=[CH:13][C:6]([CH:4]2[CH2:5][NH:2][CH2:3]2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 742994-Chlorophenylboronic acidHCID 552549914-(Azetidin-3-yl)benzonitrile hydrochloride

Product 1

HCID 717420493-(4-Chlorophenyl)azetidine--hydrogen chloride (1/1)

Procedure

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 5.2, except (4-chlorophenyl)boronic acid was used in place of (4-cyanophenyl)boronic acid. The title compound was obtained in 20% yield over two steps.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-2dbe2b6d1fe94abbbd11cae061fd2f6f
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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