Hydrogen Peroxide → HCID 178494303, compound

Participants

Reaction Steps

To a solution of 4-cyclobutyl-5-(5-methoxy-4H-1,2,4-triazol-3-yl)-2-methylbenzonitrile (compound 89.7, 0.15 g, 0.53 mmol) in EtOH (10 mL) was added NH4OH (0.18 mL, 2.66 mmol, 14.8 M in H2O), followed by H2O2 (1.8 mL, 26.6 mmol, 50% in H2O). The mixture was stirred at room temperature overnight, then cooled to 0° C. and carefully quenched with 1 M Na2S2O3 solution (26 mL). The mixture was extracted with EtOAc (×2) and the combined organic extracts were dried (Na2SO4), filtered, and concentrated under reduced pressure. The residue was purified by prep-TLC (5% MeOH in CH2Cl2) to yield 0.1 g (63%) of the title compound as a white solid. m/z (ES+) 287(M+H)+. 1H NMR (400 MHz, Methanol-d4) δ7.50 (s, 1H), 7.33 (s, 1H), 4.03 (s, 3H), 3.95-4.05 (m, 1H), 2.51 (s, 3H), 2.23-2.11 (m, 2H), 2.11-1.88 (m, 3H), 1.83-1.71 (m, 1H).

Provenance & Evidence